ANTIBACTERIAL ACTIVITY OF LIPOSOMAL AMIKACIN AGAINST PSEUDOMONAS-AERUGINOSA IN-VITRO

The influence of liposomal amikacin on Pseudomonas aeruginosa was stud ied. P. aeruginosa clinical isolates caused release of encapsulated am ikacin from liposomes, The liposomal amikacin proved to be active as b actericidal agent after 3 h of incubation with P. aeruginosa. Incubati on of P. aeruginosa with liposomal amikacin resulted in inhibition of the growth when equivalent of 2 MIC was added but not when equivalent of 1 MIC was added. Susceptibility of bacterial isolates to the liposo mal amikacin varied with bacterial strain used, but generally encapsul ation of amikacin did not enhance their antibacterial activity. (C) 19 95 The Italian Pharmacological Society