INVOLVEMENT OF THE ADENYLYL-CYCLASE SIGNALING SYSTEM IN THE ACTION OFINSULIN AND MOLLUSK INSULIN-LIKE PEPTIDE

Involvement of the adenylyl cyclase signaling system in the mechanism of action of the mammalian insulin and epidermal growth factor as well as of insulin-like peptide isolated from the bivalve mollusk Anodonta cygnea has been studied. It was shown for the first time that insulin and insulin-like peptide exert in vitro the GTP-dependent stimulating action on the adenylyl cyclase activity. Epidermal growth factor has an analogous effect. Effectiveness of the peptides decreased in the or der insulin-like peptide > epidermal growth factor > insulin in the fo ot smooth muscles of A. cygnea and insulin > epidermal growth factor > insulin-like peptide in the skeletal muscles of rat.