H. Sprinz et O. Brede, LIPID OXIDATION IN BILAYER LIPOSOMES INDUCED BY RADICALS FROM THE SURROUNDING WATER PHASES, Radiation physics and chemistry, 47(3), 1996, pp. 511-513
Citations number
8
Categorie Soggetti
Nuclear Sciences & Tecnology","Chemistry Physical","Physics, Atomic, Molecular & Chemical
Some features of the radiation chemistry of organized assemblies were
studied in aqueous dispersions of small unilamellar vesicles of egg yo
lk lecithin. The kinetics for the reaction of OH radicals with the bil
ayer was determined by pulse radiolysis. The conversion of OH radicals
into N-3 radicals results in a remarkable reduction of the radiolysis
of the hydrophylic part of the phospholipid and in an enhanced degrad
ation of the most radiosensitive group of polyunsaturated fatty acid r
esidues. The transverse proton relaxation of the choline head group is
very sensitive to the radical attack on the bilayer.