SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SUBSTITUTED BENZIMIDAZOLE, BENZOTHIAZOLE AND IMIDAZOLE DERIVATIVES

New benzimidazole, benzothiazole and imidazole derivatives were synthe sized by reacting electron-rich olefins (5, 23 and 29) with appropriat e reagents The compounds synthesized were identified by H-1, C-13-NMR, FT-IR and mass spectroscopic techniques and micro analysis. All new a nd related compounds were evaluated for their in vitro antimicrobial a ctivity against different bacteria. The compounds 17, 18, 19, 20, 21, 22 and 24 were found very effective to inhibit the growth of Enterococ cus faecalis (ATCC 29212) and Staphylococcus aureus (ATCC 29213) at mi nimum inhibitory concentrations (MICs) of 25, 25, 12.5, 50, 25, 50 and 50 mu g/ml, respectively. The compounds 4, 10a, 10c, 16, 25, 26 and 3 1 were significantly effective against Enterococcus faecalis (ATCC 292 12) and Staphylococcus aureus (ATCC 29213) with MIC values of 100-200 mu g/ml. None of the compounds proved to be effective against Escheric hia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853) in the c oncentrations studied.