C. Deckers et H. Ohgke, COMPARATIVE EFFICACY IN-VITRO OF DIFFEREN T CETYLPYRIDINIUM CHLORIDE-CONTAINING PREPARATIONS, Arzneimittel-Forschung, 45-2(12), 1995, pp. 1335-1337
The fungicidal efficacy on Candida albicans of cetylpyridinium chlorid
e (CAS 123-03-5) solution (CPC I solution, Dobendan(R)) in various dil
utions was tested with help of the quantitative suspension test and co
mpared with CPC containing self-made preparations with or without addi
tion of alcohol. The dilution of all test preparations caused an impai
rment of antimicrobial efficacy; the activity was reduced distinctly.
due to a 50% dilution a decrease of 2-3 ten's powers was observed. The
reduction of efficacy of the self-made preparation was less pronounce
d The addition of 1% albumin as well impaired the fungicidal activity
of all test preparations. CPC + alcohol revealed the most pronounced f
ungicidal efficacy, no differences were seen between CPC (without alco
hol) and CPC I solution.