COMPARATIVE EFFICACY IN-VITRO OF DIFFEREN T CETYLPYRIDINIUM CHLORIDE-CONTAINING PREPARATIONS

The fungicidal efficacy on Candida albicans of cetylpyridinium chlorid e (CAS 123-03-5) solution (CPC I solution, Dobendan(R)) in various dil utions was tested with help of the quantitative suspension test and co mpared with CPC containing self-made preparations with or without addi tion of alcohol. The dilution of all test preparations caused an impai rment of antimicrobial efficacy; the activity was reduced distinctly. due to a 50% dilution a decrease of 2-3 ten's powers was observed. The reduction of efficacy of the self-made preparation was less pronounce d The addition of 1% albumin as well impaired the fungicidal activity of all test preparations. CPC + alcohol revealed the most pronounced f ungicidal efficacy, no differences were seen between CPC (without alco hol) and CPC I solution.