AROMATIC ETHERS OF 1-ARYL 2-(1H-AZOLYL)ETHANOL - STUDY OF ANTIFUNGAL ACTIVITY

Authors
WAHBI Y CAUJOLLE R TOURNAIRE C PAYARD M LINAS MD SEGUELA JP
Citation
Y. Wahbi et al., AROMATIC ETHERS OF 1-ARYL 2-(1H-AZOLYL)ETHANOL - STUDY OF ANTIFUNGAL ACTIVITY, European journal of medicinal chemistry, 30(12), 1995, pp. 955-962
Citations number
11
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
30
Issue
12
Year of publication
1995
Pages
955 - 962
Database
ISI
SICI code
0223-5234(1995)30:12<955:AEO12->2.0.ZU;2-H
Abstract
Aromatic ethers related to antifungal azole miconazole were synthesize d and tested against various strains of Candida. We found that activit y is related to the nature of the aromatic ring and the position of su bstituents on this ring. Activity is more strongly dependent on the su bstituent in the 2 position of the ethyl chain than on the aromatic gr oup linked through the oxygen. Triazoles were always less potent than the corresponding imidazole analogues.