FACILE SYNTHESIS OF NEW AMINE HIGH-LOADED POLY(METH)ACRYLAMIDE-BASED RESINS FOR SOLID-PHASE PEPTIDE-SYNTHESIS

Two methods for the ready preparation of some protected primary amine- functionalized (meth)acrylamide derviatives from amino halides or amin o alcohols are described. The (meth)acryloyl moiety is introduced eith er in the last step from unsymmetrically N,N'-disubstituted diamines o r, more simply, in the first step, but that demands a special work-up of the reaction mixture in order to prevent polymerization. Both metho ds are complementary. Reverse phase suspension polymerization of the t itle compounds with N-acryloylpyrrolidine and N,N'-ethylenebis(acrylam ide) directly affords new beaded, high-loaded amine-functionalized res ins for solid phase peptide synthesis.