PREVENTING ABNORMALITIES IN SIGNAL-TRANSDUCTION OF T-CELLS IN CANCER - THE PROMISE OF CYTOKINE GENE-THERAPY

Recent evidence suggests that T cells from tumor-bearing patients exhi bit abnormalities in signal transduction that render them unresponsive to appropriate activation signals. Here, Karen Zier, Bernd Gansbacher and Silvia Salvadori review evidence that gene therapy with interleuk in I (IL-2)-secreting tumor-cell vaccines may prevent such signaling d efects.