KINETIC-PROPERTIES OF FLUORINATED SUBSTRATE-ANALOGS ON 5'-METHYLTHIOADENOSINE NUCLEOSIDASE FROM ESCHERICHIA-COLI

Authors
GATEL M MUZARD M GUILLERM D GUILLERM G
Citation
M. Gatel et al., KINETIC-PROPERTIES OF FLUORINATED SUBSTRATE-ANALOGS ON 5'-METHYLTHIOADENOSINE NUCLEOSIDASE FROM ESCHERICHIA-COLI, European journal of medicinal chemistry, 31(1), 1996, pp. 37-41
Citations number
24
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
31
Issue
1
Year of publication
1996
Pages
37 - 41
Database
ISI
SICI code
0223-5234(1996)31:1<37:KOFSO5>2.0.ZU;2-M
Abstract
5'-Deoxy-5'-[(monofluoromethyl)thio]adenosine, 5'-deoxy-5'-[(difluoro- methyl)thio]adenosine and 5'-deoxy-5'-[(trifluoromethyl)thio]adenosine have been evaluated for their substrate and inhibitory activities tow ard 5'-methylthioadenosine (MTA) nucleosidase from Escherichia coli. T heir abilities to serve as substrates of MTA nucleosidase support the concept that MTA nucleosidase plays a role in the biological activity of these compounds.