SYNTHESIS, BINDING-AFFINITY AND ANTIOXIDANT ACTIVITY OF NEW 1,4-DIHYDROPYRIDINES

The synthesis and in vitro pharmacology of a series of triaryl-1,4-dih ydropyridines were investigated. Molecules containing a nitro group on the phenyl ring had a higher affinity for specific [H-3](+)-PN 200-11 0 binding sites. All the compounds possessed a radical scavenging effe ct and an antiperoxidant activity. These properties were more marked f or molecules with 2-pyridinyl and 2-thienyl substituents. The synthesi s of new triaryl-1,4-dihydropyridines with both a higher binding affin ity and antioxidant activity might be effective in cerebral ischemic d isease treatment.