BIOLOGICAL STUDIES OF ANALOGS OF GLUCOSE IODINATED IN POSITION-1, POSITION-2, OR POSITION-3

Authors
KOUMANOV F HENRY C GHEZZI C BIGNAN G MORIN C MATHIEU JP HAMANT S VIDAL M DELEIRIS J COMET M
Citation
F. Koumanov et al., BIOLOGICAL STUDIES OF ANALOGS OF GLUCOSE IODINATED IN POSITION-1, POSITION-2, OR POSITION-3, Nuclear medicine and biology, 23(1), 1996, pp. 53-60
Citations number
45
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051 → ACNP
Volume
23
Issue
1
Year of publication
1996
Pages
53 - 60
Database
ISI
SICI code
0969-8051(1996)23:1<53:BSOAOG>2.0.ZU;2-9
Abstract
Analogues of glucose labeled with 123 iodine in positions 1, 2 or 3 ha ve been synthesized. The aim of this study was to examine their biolog ical behavior in four experimental models in order to assess whether t hey could be used to evaluate the uptake of glucose with single photon emission computed tomography (SPECT). The results obtained have shown that none of these molecules enters the cell using the glucose transp orter. Therefore, they cannot be used as tracers of glucose uptake.