SYNTHESIS AND INCLUSION PROPERTIES OF PYRIDINOPHANE-LINKED MACROCYCLES

The macrocyclic host molecules 1 and 2 have been synthesized in satisf actory yields. These cyclophane-linked structures produce electron-ric h cavities because the lone pairs of 2,11-diaza[3.3](2,6)-pyridinophan e and pyridine rings converge into the cavities. Although compound 1 s trongly binds guanidinium ion and urea, compound 2 showed weak complex ation toward these guests, In the inclusion of guests by hydrogen bond s, the cooperation of the pyridinophane donor sites plays a very impor tant role, Interestingly, 1 adsorbed water molecules in solution to gi ve the hydrated compound 1 . 6H(2)O.