BACKGROUND: Keratomileusis in situ, particularly automated lamellar ke
ratoplasty, is a commonly performed technique of keratomileusis in the
United States. METHODS: A single center consecutive series of 152 eye
s undergoing keratomileusis in situ for myopia was analyzed. Spherical
equivalent refractions were compared before and after surgery. The st
andard nomogram supplied with the automatic corneal shaper (Chiron Vis
ion Corp, Irvine, Calif) was used. The mean of preoperative myopia tre
ated was -9.30 +/- 3.10 diopters (D) (range, -5.12 to -22.75 D). RESUL
TS: Of the 144 eyes with 1 month follow up, 30 (21%) were within 0.50
D of the planned correction at 1 month, 54 (38%) were within 1.00 D, a
nd 97 (67%) were within 2.00 D. At 6 or more months follow up, 51 of 6
8 eyes (75%) achieved uncorrected visual acuity of 20/40 or better and
13 of 68 (19%) 20/20 or better when eyes with macular degeneration an
d amblyopia were removed. Forty-six of 78 eyes (59%) with 6 months or
greater follow up required retreatment procedures to correct residual
myopia or astigmatism Multiple regression analysis explained 40% of th
e variation between attempted correction and postoperative results. An
overall 5% shift of refraction in the myopic direction occurred betwe
en 1 and 6 months. Of the 110 eyes with both 1- and 3-month examinatio
ns, the spherical equivalent refraction changed between these time int
ervals by 1.00 D or more in 54 (49%) eyes; and 11 (31%) eyes changed b
y 1.00 D or more between the 3- and g-month examinations. Although 6%
of eyes lost 2 or more lines of spectacle-corrected visual acuity, 11%
gained 2 or more lines. CONCLUSION: Myopic keratomileusis in situ usi
ng the automated lamellar keratoplasty technique appears to be a safe
and most effective procedure to reduce moderate to high myopia. Howeve
r, the predictability of the procedure needs improvement.