We study the effect of changing buffer sizes in serial lines with gene
ral blocking, a mechanism that incorporates limited intermediate finis
hed goods inventory at each stage, as well as limited intermediate raw
material inventory. This model includes ordinary manufacturing, commu
nication, and kanban blocking as special cases. We present conditions
under which increasing buffer sizes or re-allocating buffer capacity i
ncreases throughput, and in some cases characterize optimal allocation
s. Our comparisons hold pathwise; they depend on structural properties
of a line but not its service time distributions. The key to our anal
ysis is formulating the model as a generalized semi-Markov process (GS
MP). We show that a serial line with general blocking possesses variou
s structural properties from which pathwise comparisons follow directl
y, making a detailed case-by-case analysis unnecessary These results h
elp illustrate the power of GSMPs as a modeling framework.