Tj. Degroot et al., IN-VITRO EVALUATION OF N-(FLUORO)ISOPROPYL NOREPHEDRINE AS POTENTIAL CARDIAC IMAGING AGENTS FOR PET, Nuclear medicine and biology, 23(2), 1996, pp. 155-157
N-Isopropylnorephedrine (INE) and N-fluoroisopropylnorephedrine (FINE)
were found to have a poor affinity for either P-adrenoceptors and the
norepinephrine carrier protein. The low affinity of both compounds fo
r Uptake-1 is probably due to the introduction of a bulky substituent
on the nitrogen atom. It is concluded that INE and FINE cannot be used
for cardiac imaging with PET.