IN-VITRO EVALUATION OF N-(FLUORO)ISOPROPYL NOREPHEDRINE AS POTENTIAL CARDIAC IMAGING AGENTS FOR PET

Authors
DEGROOT TJ BUITENHUIS CKM RUTGERS M VANWAARDE A VISSER GM SMETS LA BRODDE OE VAALBURG W
Citation
Tj. Degroot et al., IN-VITRO EVALUATION OF N-(FLUORO)ISOPROPYL NOREPHEDRINE AS POTENTIAL CARDIAC IMAGING AGENTS FOR PET, Nuclear medicine and biology, 23(2), 1996, pp. 155-157
Citations number
12
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051 → ACNP
Volume
23
Issue
2
Year of publication
1996
Pages
155 - 157
Database
ISI
SICI code
0969-8051(1996)23:2<155:IEONNA>2.0.ZU;2-5
Abstract
N-Isopropylnorephedrine (INE) and N-fluoroisopropylnorephedrine (FINE) were found to have a poor affinity for either P-adrenoceptors and the norepinephrine carrier protein. The low affinity of both compounds fo r Uptake-1 is probably due to the introduction of a bulky substituent on the nitrogen atom. It is concluded that INE and FINE cannot be used for cardiac imaging with PET.