FREE-RADICAL SCAVENGING ACTIVITY OF CURCUMINOIDS

Citation
N. Sreejayan et Mna. Rao, FREE-RADICAL SCAVENGING ACTIVITY OF CURCUMINOIDS, Arzneimittel-Forschung, 46(2), 1996, pp. 169-171
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00044172
Volume
46
Issue
2
Year of publication
1996
Pages
169 - 171
Database
ISI
SICI code
0004-4172(1996)46:2<169:FSAOC>2.0.ZU;2-O
Abstract
Three natural curcuminoids (curcumin (CAS 458-37-7), demethoxycurcumin , bisdemethoxycurcumin) and acetylcurcumin were compared for their abi lity to scavenge superoxide radicals and to interact with 1,1-diphenyl -2-picryl-hydrazyl (DPPH) stable free radicals. The results showed tha t curcumin is the most potent scavenger of superoxide radicals followe d by demethoxycurcumin and bisdemethoxycurcumin. Acetylcurcumin was in active. Interaction with DPPH showed a similar activity profile. The s tudy indicates that the phenolic group is essential for the free radic al scavenging activity and presence of methoxy group further increases the activity.