Gl. Silva et al., NOVEL CYTOTOXIC RING-A SECO-CYCLOARTANE TRITERPENES FROM GARDENIA-CORONARIA AND GARDENIA-SOOTEPENSIS, Tetrahedron, 53(2), 1997, pp. 529-538
Coronalolide methyl ester (1), coronalolide (2), and coronalolic acid
(3) were isolated from the leaves and/or stems of Gardenia coronaria.
A further compound, methyl coronalolate acetate (4), was purified from
the stems after methylation. The novel compounds 1-4 have the rare ri
ng-A seco-cycloartane carbon skeleton and their structures were assign
ed on the basis of spectral data and molecular modeling, as well as X-
ray crystallography performed on 1. Compounds 1 and 2 were also isolat
ed from the leaves of Gardenia sootepensis and showed broad cytotoxic
activity when evaluated against a panel of human cancer cell lines. Co
pyright (C) 1996 Elsevier Science Ltd