Five cases of spontaneous coronary artery dissection (SCAD) are report
ed, three in women and two in men (mean age 44 years; range 28-65), al
l of whom suffered a myocardial infarction. Common risk factors for co
ronary artery disease were present in the two men; in the female group
one patient was taking an oral contraceptive, one was in the postpart
um period, and the third was a smoker. Only the three women received i
ntravenous alteplase and their ejection fraction was normal; both men
had impaired left ventricular function. Two patients had SCAD of the l
eft anterior descending coronary artery and three of the right coronar
y artery. Only the two men had angiographic features of coronary ather
osclerotic involvement. No patients required surgical revascularisatio
n or percutaneous transluminal coronary angioplasty. At a mean follow
up of 27 months (range 6 to 40) all patients were alive and all but on
e were asymptomatic.