SYNTHESIS OF C-11 CHAIN-EXTENDED ANALOGS OF N-ACETYLNEURAMINIC ACID

Authors
KIEFEL MJ BENNETT S VONITZSTEIN M
Citation
Mj. Kiefel et al., SYNTHESIS OF C-11 CHAIN-EXTENDED ANALOGS OF N-ACETYLNEURAMINIC ACID, Journal of the Chemical Society. Perkin transactions. I, (5), 1996, pp. 439-442
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
5
Year of publication
1996
Pages
439 - 442
Database
ISI
SICI code
0300-922X(1996):5<439:SOCCAO>2.0.ZU;2-9
Abstract
The synthesis of novel C-11 chain-extended analogues of N-acetylneuram inic acid has been achieved from the N-acetyl-9-hydroxyneuraminic acid derivative 7 via a Swern oxidation/Wittig olefination sequence. In th is way the novel alpha,beta-unsaturated ester 12, the saturated ester 13 and the alpha,beta-unsaturated aldehyde 14 of N-acetylneuraminic ac id have been prepared in good overall yield.