SYNTHESIS AND INFLUENZA-VIRUS SIALIDASE INHIBITORY ACTIVITY OF ANALOGS OF 4-GUANIDINO-NEU5AC2EN (GG167) WITH MODIFIED 5-SUBSTITUENTS

Authors
SMITH PW STARKEY ID HOWES PD SOLLIS SL KEELING SP CHERRY PC VONITZSTEIN M WU WY JIN B
Citation
Pw. Smith et al., SYNTHESIS AND INFLUENZA-VIRUS SIALIDASE INHIBITORY ACTIVITY OF ANALOGS OF 4-GUANIDINO-NEU5AC2EN (GG167) WITH MODIFIED 5-SUBSTITUENTS, European journal of medicinal chemistry, 31(2), 1996, pp. 143-150
Citations number
17
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
31
Issue
2
Year of publication
1996
Pages
143 - 150
Database
ISI
SICI code
0223-5234(1996)31:2<143:SAISIA>2.0.ZU;2-N
Abstract
Analogues of 4-guanidino-Neu5Ac2en (GG167) have been prepared containi ng alternative amide and sulfonamide substituents at the 5-position. r ihydroxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid 5 and rihydroxy propyl)-5,6-dihydro-4H-pyran-2-carboxylic acid 6 were the only analogu es which approached the activity of GG167, showing potent inhibition o f influenza virus sialidases and good antiviral activity in vitro.