POLY (D,L-LACTIDE) GLYCOLIDE POLYMER MICROSPHERE ENTRAPPED TETANUS TOXOID - SAFETY EVALUATION IN WISTAR RATS

Authors
CHAUDHURY MR SHARMA K GIRI DK
Citation
Mr. Chaudhury et al., POLY (D,L-LACTIDE) GLYCOLIDE POLYMER MICROSPHERE ENTRAPPED TETANUS TOXOID - SAFETY EVALUATION IN WISTAR RATS, Human & experimental toxicology, 15(3), 1996, pp. 205-207
Citations number
14
Categorie Soggetti
Toxicology
Journal title
Human & experimental toxicology → ACNP
ISSN journal
09603271
Volume
15
Issue
3
Year of publication
1996
Pages
205 - 207
Database
ISI
SICI code
0960-3271(1996)15:3<205:P(GPME>2.0.ZU;2-8
Abstract
A vaccine preparation consisting of tetanus toroid (TT) encapsulated i n biodegradable poly (D,L-Lactide) glycolide polymer has been develope d. The toxicity of the preparation was evaluated in adult male and fem ale Wistar rats injected IM with 20, 100 and 200 Lf tetanus toroid, in polymer in 0.5 ml vehicle. No adverse effect of the vaccine could be seen, except for a granulomatous reaction at the site of injection. Th e vaccine was considered safe based on the findings in rats of both se xes.