Vm. Mazhul et al., PHOSPHORESCENT ANALYSIS OF GROWTH-FACTOR EFFECT ON INTRAMOLECULAR DYNAMICS OF MEMBRANE-PROTEINS OF RAT PHEOCHROMOCYTOMA CELLS RS12, Doklady Akademii nauk BSSR, 39(6), 1995, pp. 83-86
Using method of tryptophan phosphorescence at room temperature the eff
ect of epidermal growth factor and nerve growth factor on the dynamica
l structure of membrane proteins of rat pheochromocytoma PC12 cells wa
s studied. It was shown that variation of frequency and amplitude of e
quilibrium large-scale motions of membrane protein structure is one of
the early events initiated by growth factors.