PRETREATMENT AND POSTTREATMENT TUMOR ENERGY-CHARGE AND ANTITUMOR EFFECT OF LOCAL HYPERTHERMIA IN-VIVO

Interrelationship between tumour energy charge (TEC) and antitumour ef fect of local microwave hyperthermia (HT) analyzed by tumour growth de lay (TGD) assay was investigated in in vivo experiments with s.c. Guer in carcinoma. Adenylate concentrations were determined by HPLC in tumo ur biopsy obtained immediately before and after heating. It was establ ished that pre-treatment TEC did not correlate with TGD. At the same t ime, post-treatment TEC has a negative correlation with Too: correlati on coefficient is -0.7 (P < 0.01). It was suggested that tumour perfus ion rate before HT plays a crucial role for realization of HT effect o n tumour, while tumour energy status after heating has a significant i mportance for HT end-point result.