STEREOSPECIFIC SYNTHESIS OF (2S,4R)-[5,5,5-H-2(3)]LEUCINE

Authors
AUGUST RA KHAN JA MOODY CM YOUNG DW
Citation
Ra. August et al., STEREOSPECIFIC SYNTHESIS OF (2S,4R)-[5,5,5-H-2(3)]LEUCINE, Journal of the Chemical Society. Perkin transactions. I, (6), 1996, pp. 507-514
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
6
Year of publication
1996
Pages
507 - 514
Database
ISI
SICI code
0300-922X(1996):6<507:SSO(>2.0.ZU;2-4
Abstract
The first stereospecific chemical synthesis of a sample of the amino a cid (2S)-leucine labelled in one of the diastereotopic methyl groups h as been achieved using (2S)-pyroglutamic acid as a chiral template, Th is has been used to develop a method for assigning resonances to the d iastereotopic methyl groups of the leucine residues in the H-1 NMR spe ctra of proteins.