O. Soylemezoglu et al., CIRCULATING ADHESION MOLECULES ICAM-1, E-SELECTIN, AND VON-WILLEBRAND-FACTOR IN HENOCH-SCHONLEIN PURPURA, Archives of Disease in Childhood, 75(6), 1996, pp. 507-511
Adhesion molecules play an important part in leucocyte transendothelia
l migration and thus may provide a useful marker of surface expression
at inflammatory sites. In 20 patients with Henoch-Schonlein purpura a
dhesion molecule E-selectin, and plasma von Willebrand factor (vWF) we
re determined by ELISA during the active and inactive phase of the Twe
lve healthy children were as a control group. Serum ICAM-1 concentrati
ons increased during the active phase of the disease and differed sign
ificantly compared with the inactive phase (p<0.05). However ICAM-1 in
the active phase did not differ significantly compared with controls
(p=0.08). Serum E-selectin concentrations did not differ in the active
and inactive phase of the disease. By contrast, vWF increased in the
active phase of the disease and differed significantly compared with i
nactive disease and control groups (p<0.01). Considering the adhesion
molecules and vWF, only vWF correlated well with the C reactive protei
n measurement in the active phase, which is considered a good marker o
f disease activity. These data suggest that plasma vWF is a good marke
r of vascular inflammation and endothelial damage. Circulating ICAM-1
might be an additional parameter in some of the patients.