Ab. Erkilic et al., THE INFLUENCE OF BLOOD-PRESSURE ON INTRACELLULAR CA2- EFFECTS OF CADMIUM CHLORIDE AND NIFEDIPINE( CONTENT IN ERYTHROCYTES ), Clinical and experimental hypertension, 18(1), 1996, pp. 77-86
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy","Cardiac & Cardiovascular System
Cellular abnormalities associated with elevated Ca2+ concentrations ha
ve been postulated to be involved in the pathogenesis of hypertension.
The present study was undertaken to investigate the effects of blood
pressure changes on cytosolic Ca2+ levels in erythrocytes. Cadmium, wh
ich has been implicated in the etiology of hypertension was used as th
e hypertensive agent and the classical blocker of voltage-operated cal
cium channels nifedipine was used to treat hypertension. 10 weeks old
male rats were divided into four groups; control, CdCl2, CdCl2 and nif
edipine, nifedipine groups. CdCl2 caused elevations in blood pressure
and in the cytosolic erythrocyte Ca2+ levels both of which were reduce
d after nifedipine administration. After nifedipine alone, cytosolic C
a2+ levels were increased. These findings suggest that cytosolic Ca2content decreasing action of nifedipine in the CdCl2 and nifedipine ap
plied group could be secondary to the antihypertensive action.