ASSIGNMENT OF THE GENE ENCODING TYPE 1-GAMMA PROTEIN PHOSPHATASE CATALYTIC SUBUNIT (PPP1CC) ON HUMAN, RAT, AND MOUSE CHROMOSOMES

Using fluorescent in situ hybridization (FISH) method, a gene encoding the catalytic subunit of protein phosphatase type 1 gamma (PPP1CC) wa s mapped to human 12q24.1-q24.2, rat 7q22, and mouse 10C. These result s indicate that the PPP1CC is a member of conserved synteny group betw een rat chromosome 7, mouse chromosome 10 and human chromosome 12. The se data and mapping data about other members of PP1 family show that i n spite of the high identity of PP1 isoforms, each isoform is encoded by different genes which located on different chromosomes in human, ra t, and mouse.