SYNTHESIS AND EFFECTS ON ARGINASE AND NITRIC-OXIDE SYNTHASE OF 2 NOVEL ANALOGS OF N-OMEGA-HYDROXYARGININE, N-OMEGA-HYDROXYINDOSPICINE AND P-HYDROXYAMIDINOPHENYLALANINE

Two novel amino acids, N-omega-hydroxy-D,L-indospicine and p-hydroxyam idino-D,L-phenylalanine, have been synthesized in four steps from tert -butoxycarbonylglycine. Both compounds act as good inhibitors of argin ase, N-omega-hydroxyindospicine being one of the best inhibitors of th is enzyme known so far (IC50 = 50 mu mol dm(-3)). In contrast, with br ain NO synthase the two compounds are almost without effect.