EMBRYOTOXICITY AND TERATOGENICITY STUDIES OF POLY (DL-LACTIDE-CO-GLYCOLIDE) MICROSPHERES INCORPORATED TETANUS TOXOID IN WISTAR RATS

Authors
CHANDRASEKARAN R GIRI DK CHAUDHURY MR
Citation
R. Chandrasekaran et al., EMBRYOTOXICITY AND TERATOGENICITY STUDIES OF POLY (DL-LACTIDE-CO-GLYCOLIDE) MICROSPHERES INCORPORATED TETANUS TOXOID IN WISTAR RATS, Human & experimental toxicology, 15(4), 1996, pp. 349-351
Citations number
15
Categorie Soggetti
Toxicology
Journal title
Human & experimental toxicology → ACNP
ISSN journal
09603271
Volume
15
Issue
4
Year of publication
1996
Pages
349 - 351
Database
ISI
SICI code
0960-3271(1996)15:4<349:EATSOP>2.0.ZU;2-M
Abstract
Tetanus Toroid loaded biodegradable microspheres (MTT) (poly (DL-Lacti de-co-Glycolide) were administered intramuscularly to pregnant Wistar rats from Days 6 to 15 of gestation, at 1, 5 and 10-times the human eq uivalent dose of TT. Developmental defects in relation to soft tissues and skeleton, weight and sex of live pups and early fetal deaths from treated and control rats were analysed. The findings in treatment gro ups were comparable to those in the controls. These observations show that MTT was safe for pregnant rats and developing pups.