Background. Patients with head and neck neoplasms receive therapeutic
neck dissections which may include the submandibular gland unilaterall
y or bilaterally. The clinical consequences of salivary gland resectio
n could be reduced salivary output, altered cariogenic microflora, and
increased incidence of denial caries. Methods, This investigation eva
luated whole salivary flow rates of patients who had received unilater
al (n = 29) or bilateral (n = 8) submandibular gland resections and co
mpared them with noncancer control subjects (n = 29), Results. Unstimu
lated and stimulated (paraffin) flow rates were significantly lower in
both resection groups compared with those of the noncancer group, ran
ging from p <.002 to p <.02. Although flow rates were lower in the bil
ateral group than in the unilateral group, the differences between the
se two groups were statistically significant (p <.02) only for stimula
ted saliva. Xerostomia was reported by one third of the resection subj
ects. Conclusions. In view of the significantly lower flow rates obser
ved in the resection groups (especially for unstimulated saliva), topi
cal fluoride therapy should be considered for those patients whose pas
t caries activity would indicate an increased caries risk associated w
ith partial loss of salivary function.