ALUMINUM AND PHOSPHORUS URINARY-EXCRETION AFTER MODIFYING GASTRIC-ACID SECRETION IN CHRONIC-RENAL-FAILURE

12 healthy volunteers (6 males, 6 females) and 16 patients with chroni c renal failure (CRF) (8 males, 8 females) were prescribed for 3 weeks a diet with a caloric intake adequate to age and body weight. In the second week they were given aluminum hydroxide (Al-hy), 4 g per day in 2 divided doses. In the third week they took Al-hy + omeprazole (20 m g once a day). At the end of the weeks 1, 2, and 3, urine (over 24-hou r period) and blood samples were collected. The oral load of Al-hy in controls produces increased levels of serum (Al-s) and urine (Al-u) al uminum, while the concomitant use of omeprazole does not modify Al-s, but reduces Al-u. In CRF, oral load of Al-hy produces increased levels of Al-s and Al-u, while the concomitant use of omeprazole does not mo dify Al-s and Al-u vs Al-hy. Omeprazole use neither alters serum phosp horus levels nor hinders reduction of urine phosphorus excretion, caus ed by Al-hy in the second group.