INFLUENCE OF DIFFERENT TYPES OF CYCLODEXTRINS ON THE RACEMIZATION OF SCOPOLAMINE-N-BUTYLBROMIDE

Authors
BUNKE A JIRA T BEYRICH T
Citation
A. Bunke et al., INFLUENCE OF DIFFERENT TYPES OF CYCLODEXTRINS ON THE RACEMIZATION OF SCOPOLAMINE-N-BUTYLBROMIDE, Journal of chromatography, 728(1-2), 1996, pp. 441-445
Citations number
12
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of chromatography → ACNP
Volume
728
Issue
1-2
Year of publication
1996
Pages
441 - 445
Database
ISI
SICI code
Abstract
The influence of cyclodextrins (CDs) on the racemization and hydrolysi s of scopolamine-N-butylbromide was determined kinetically. alpha-CD a nd gamma-CD enhance the racemization rate of the substance. beta-CD sh ows no effect and DM-beta-CD (dimethyl-beta-CD) causes inhibition of r acemization. The hydrolysis of the substance was retarded by beta-, ga mma- and DM-beta-CD. In the presence of alpha-CD no change in hydrolys is rate was observed.