A CLINICAL-TRIAL FOR THE TREATMENT OF ANTIPHOSPHOLIPID ANTIBODY-ASSOCIATED RECURRENT PREGNANCY LOSS WITH LOWER DOSE HEPARIN AND ASPIRIN

This study was conducted to determine if lower dose heparin (LD Hepari n) combined with aspirin is as efficacious as higher dose heparin (HD Heparin) for the treatment of the antiphospholipid antibody syndrome i n women seeking pregnancy. The method of the study was a prospective, single center trial including 50 patients who were consecutively assig ned to treatment. Each patient had at least three consecutive, spontan eous pregnancy losses, positive antiphospholipid antibodies on two occ asions, and a complete evaluation. Data were compared using Fisher's e xact test. Viable infants were delivered from 20/25 (80%) women treate d with higher dose heparin vs. 19/25 (76%) of women treated with lower dose heparin. There were no significant differences between groups wi th respect to gestational age at the time of delivery (37.2 +/- 3.4 ve rsus 37.7 +/- 1.6 weeks), maternal complications, or fetal complicatio ns. A lower dose of heparin plus aspirin was as effective as higher do se heparin for the treatment of antiphospholipid antibody-associated r ecurrent pregnancy loss.