SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF C-3 SUBSTITUTED TRIAZOLYLTHIOMETHYL CEPHEMS

Authors
SINGH R FIAKPUI C GALPIN J STEWART J SINGH MP MICETICH RG
Citation
R. Singh et al., SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF C-3 SUBSTITUTED TRIAZOLYLTHIOMETHYL CEPHEMS, European journal of medicinal chemistry, 31(4), 1996, pp. 301-309
Citations number
19
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
31
Issue
4
Year of publication
1996
Pages
301 - 309
Database
ISI
SICI code
0223-5234(1996)31:4<301:SASROC>2.0.ZU;2-E
Abstract
A series of C-3 substituted triazolylthiomethyl cephems with an aminot hiazolemethoxyiminoacetamido side chain at C-7 were synthesized and te sted for antimicrobial activity against clinically-relevant isolates. The compound with 3-pyridyl at C-5 and methyl at N-4 of the triazole m oiety exhibited good antibacterial activity against both Gram-positive and Gram-negative bacteria, with the exception of pseudomonas spp aga inst which none of the derivatives exhibited favorable activity.