SYNTHESIS AND ANTICONVULSANT ACTIVITY OF A SERIES OF BENZAMIDES

Authors
MUSSO DL BOSWELL GE MEHTA NB SOROKO FE BURCHALL CJ
Citation
Dl. Musso et al., SYNTHESIS AND ANTICONVULSANT ACTIVITY OF A SERIES OF BENZAMIDES, European journal of medicinal chemistry, 31(4), 1996, pp. 331-334
Citations number
11
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
31
Issue
4
Year of publication
1996
Pages
331 - 334
Database
ISI
SICI code
0223-5234(1996)31:4<331:SAAAOA>2.0.ZU;2-6
Abstract
A series of benzamides containing N,N,2-trimethyl-1,2-propane diamine as the amide moiety was synthesized. The compounds were evaluated in t he maximal electroshock (MES) and pentylenetetrazol (metrazole, MET) s creens for anticonvulsant activity. The 3,5-trifluoromethyl, 3,5-dichl oro, and 3-bromo analogues proved to be either equipotent with or more potent than phenytoin.