RENAL COMPENSATION FOR CECAL LOSS IN GAMBELS QUAIL (CALLIPEPLA-GAMBELII)

Some studies have implicated the avian digestive cecae as important si tes of water and solute reclamation working in concert with the lower intestine and the kidneys as part of an integrated osmoregulatory syst em. In Gambel's quail (Callipepla gambelii), we studied compensatory a djustments in renal function on days 6-7 and 16-17 following ligation of cecae. Plasma osmolality (P-osm) varied significantly between group s with sham-operatd birds (Cs), with an average (P-osm) of 348 mOsm/kg H2O and quail with ligated cecae (Cx) having a (P-osm) of 355 mOsm/kg H2O. We detected no change in the rate of glomerular filtration (GFR) between experimental and control groups either shortly after cecectom y or after 16-17 d Following surgery. Regression analysis of GFR and u rine flow rate (V) showed that Cx birds had a significantly lower V at a given GFR than did controls, evidence that Cx quail absorbed more f luid in their renal tubules. Increased fluid reabsorption was apparent ly driven by an enhanced reabsorption of sodium. Indeed, sodium excret ion was lower in Cx quail as compared to sham operated birds. On days 6-7, Cx quail drank more water than Cs birds, but by days 16-17 drinki ng rates were similar. At the end of the experiments, Cx quail showed a proliferation of microvilli along the apical membrane of the rectum, an adjustment consistent with the idea that the rectum alters its abs orption capacity to adjust for the loss of cecal function.