RAPID-DETERMINATION OF RESIDUAL TRICHLOROMETHANE IN DRUGS

Citation
Wq. Guo et al., RAPID-DETERMINATION OF RESIDUAL TRICHLOROMETHANE IN DRUGS, Journal of chromatography, 731(1-2), 1996, pp. 361-364
Citations number
10
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Volume
731
Issue
1-2
Year of publication
1996
Pages
361 - 364
Database
ISI
SICI code
Abstract
Thermal desorption-gas chromatography is reported as a rapid, efficien t and sensitive method for separating and determining the trace volati le organic impurities in drugs with a detection limit of 23 nmol. The optimum operating conditions were found and CHCl3 in atropine sulfate and caffeine was determined with satisfactory results. This method is suitable for determining trace volatile impurities in solid samples an d high-boiling liquid samples.