SOLID-PHASE GLYCOPEPTIDE SYNTHESIS OF TYROSINE-GLYCOSYLATED GLYCOGENIN FRAGMENTS AS SUBSTRATES FOR GLUCOSYLATION BY GLYCOGENIN

Authors
JANSSON AM JENSEN KJ MELDAL M LOMAKO J LOMAKO WM OLSEN CE BOCK K
Citation
Am. Jansson et al., SOLID-PHASE GLYCOPEPTIDE SYNTHESIS OF TYROSINE-GLYCOSYLATED GLYCOGENIN FRAGMENTS AS SUBSTRATES FOR GLUCOSYLATION BY GLYCOGENIN, Journal of the Chemical Society. Perkin transactions. I, (10), 1996, pp. 1001-1006
Citations number
40
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
10
Year of publication
1996
Pages
1001 - 1006
Database
ISI
SICI code
0300-922X(1996):10<1001:SGSOTG>2.0.ZU;2-6
Abstract
The four building blocks N-alpha-Fmoc-Tyr(Bz(4)-alpha-D-Glc)-OPfp 1, N -alpha-Fmoc-Tyr(Bz(4)-beta-D-Glc)-OPfp 2, N-alpha-Fmoc-Tyr [Bz(4)-alph a-D-Glc-(1-->4)-Bz(3)-alpha-D-Glc]-OPfp 3 and Tyr[Ac-4-alpha-D-Glc-(1- ->4)-Ac-3-beta-D-Glc]-OPfp 4 were used in continuous-how solid-phase s ynthesis of four 25-amino-acid-long glycopeptides 5-8 related to glyco genin, The unglycosylated peptide 9 was synthesized as well, and the f ive glycogenin fragments were tested as accepters for glucosyl transfe r by recombinant glycogenin.