SUSCEPTIBILITY OF PSEUDOMONAS-AERUGINOSA SEROTYPE-011 ISOLATES TO AMINOGLYCOSIDE AND BETA-LACTAM ANTIBIOTICS AND MECHANISMS OF RESISTANCE

Susceptibility of Pseudomonas aeruginosa serotype 011 clinical isolate s originating from Bratislava hospitals to aminoglycosides and beta-la ctam antibiotics and mechanisms of their resistance were studied. Rand omly chosen 16 isolates showed resistance to all five aminoglycosides studied: gentamicin (G), tobramycin (T), netilmicin (N), amikacin (A), and isepamicin (I). The most frequent resistance mechanism (13 isolat es:) was production of aminoglycoside-modifying enzymes (AGME), mainly AAC(6')-I, APH(2 '') and APH(3')-VI. All 16 isolates had indistinguis hable beta-lactam resistance, 2 isolates were resistant to imipenem as well. Six strains produced a beta-lactamase responsible for resistanc e to beta-lactam tested.