MULTIPLE GENETIC ABNORMALITIES OF 11P15 IN WILMS-TUMOR

Authors
FEINBERG AP
Citation
Ap. Feinberg, MULTIPLE GENETIC ABNORMALITIES OF 11P15 IN WILMS-TUMOR, Medical and pediatric oncology, 27(5), 1996, pp. 484-489
Citations number
61
Categorie Soggetti
Oncology,Pediatrics
Journal title
Medical and pediatric oncology → ACNP
ISSN journal
00981532
Volume
27
Issue
5
Year of publication
1996
Pages
484 - 489
Database
ISI
SICI code
0098-1532(1996)27:5<484:MGAO1I>2.0.ZU;2-Y
Abstract
Wilms' tumor has served as a model of multiple genetic alterations in childhood cancer. This review summarizes work in our laboratory identi fying several of these alterations. These include the localization to 11p15 of an embryonal tumor suppressor gene and at least one gene for Beckwith-Wiedemann syndrome, which predisposes to Wilms' tumor; as wel l as a novel mutational mechanism in man, loss of imprinting. (C) 1996 Wiley-Liss, Inc.