DETERMINATION OF ABSOLUTE-CONFIGURATION AND BIOLOGICAL-ACTIVITY OF NEW IMMUNOSUPPRESSANTS, MYCESTERICIN-D, MYCESTERICIN-E, MYCESTERICIN-F AND MYCESTERICIN-G

Authors
FUJITA T HAMAMICHI N KIUCHI M MATSUZAKI T KITAO Y INOUE K HIROSE R YONETA M SASAKI S CHIBA K
Citation
T. Fujita et al., DETERMINATION OF ABSOLUTE-CONFIGURATION AND BIOLOGICAL-ACTIVITY OF NEW IMMUNOSUPPRESSANTS, MYCESTERICIN-D, MYCESTERICIN-E, MYCESTERICIN-F AND MYCESTERICIN-G, Journal of antibiotics, 49(9), 1996, pp. 846-853
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
9
Year of publication
1996
Pages
846 - 853
Database
ISI
SICI code
0021-8820(1996)49:9<846:DOAABO>2.0.ZU;2-#
Abstract
Mycestericins D, E, F and G were isolated from the culture broth of My celia sterilia ATCC 20349 as potent immunosuppressants. Mycestericins F and G were identical with dihydromycestericins D and E, respectively . Their absolute configurations were determined by use of the modified MOSHER's method and by comparison of the CD spectra of their benzoate derivatives with those of synthetic analogs. Mycestericins D, E, F an d G suppressed the proliferation of lymphocytes in the mouse allogenei c mixed lymphocyte reaction.