ISOLATION AND STRUCTURE ELUCIDATION OF 5 NEW ASTERRIQUINONES FROM ASPERGILLUS, HUMICOLA AND BOTRYOTRICHUM SPECIES

Authors
MOCEK U SCHULTZ L BUCHAN T BAEK C FRETTO L NZEREM J SEHL L SINHA U
Citation
U. Mocek et al., ISOLATION AND STRUCTURE ELUCIDATION OF 5 NEW ASTERRIQUINONES FROM ASPERGILLUS, HUMICOLA AND BOTRYOTRICHUM SPECIES, Journal of antibiotics, 49(9), 1996, pp. 854-859
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
9
Year of publication
1996
Pages
854 - 859
Database
ISI
SICI code
0021-8820(1996)49:9<854:IASEO5>2.0.ZU;2-C
Abstract
Five new quinone pigments have been discovered from the fermentation b roth of Aspergillus, Humicola and Botryotrichum species isolated from different soil samples. These compounds inhibit serine proteases of th e coagulation pathway. Their structures which differ in the identity a nd position of a 5-carbon side chain on the indole moiety have been el ucidated based on NMR and FAB-MS experiments.