PYRROLOSPORIN-A, A NEW ANTITUMOR ANTIBIOTIC FROM MICROMONOSPORA SP C39217-R109-7 .2. ISOLATION, PHYSICOCHEMICAL PROPERTIES, SPECTROSCOPIC STUDY AND X-RAY-ANALYSIS

Authors
SCHROEDER DR COLSON KL KLOHR SE LEE MS MATSON JA
Citation
Dr. Schroeder et al., PYRROLOSPORIN-A, A NEW ANTITUMOR ANTIBIOTIC FROM MICROMONOSPORA SP C39217-R109-7 .2. ISOLATION, PHYSICOCHEMICAL PROPERTIES, SPECTROSCOPIC STUDY AND X-RAY-ANALYSIS, Journal of antibiotics, 49(9), 1996, pp. 865-872
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
9
Year of publication
1996
Pages
865 - 872
Database
ISI
SICI code
0021-8820(1996)49:9<865:PANAAF>2.0.ZU;2-2
Abstract
Pyrrolosporin A (1) is a new macrolide antitumor antibiotic possessing an unusual spiro-alpha-acyltetronic acid moiety. The antibiotic was i solated from the fermentation broth of Micromonospora sp. by vacuum li quid chromatography, crystallization and reversed phase HPLC (C18). Th e structure was determined by a combination of NMR, MS, IR, UV, X-ray analysis and degradation studies.