COMPUTER MODELING OF NON-ADJACENT REGIONAL ISCHEMIC ZONES ON VENTRICULAR-FUNCTION

Multiple regional myocardial ischemia that leads to depressed left ven tricular (LV) function is commonplace. Quantitative analysis of the he modynamic consequences, however, has been limited. We investigated thi s aspect using a novel computer model of the cardiovascular system. Th e model consists of an LV with two ischemic zones (IZs) and a normal z one (NZ), the. preload, and the arterial system afterload. The IZ size and activation timing could be altered. Results show that the greater the size and activation asynchronization between NZ and IZ, the more severe the LV dysfunction. Increased preload during ischemia improved LV function. This computer model predicts features that agree well wit h reported experimental observations and is particularly useful for my ocardial ischemic function analysis.