KINETICS OF THE FORMATION AND HYDROLYSIS OF THE SCHIFF-BASES OF PYRIDOXAL 5'-PHOSPHATE AND COPOLYPEPTIDES CONTAINING L-LYSINE AND AROMATIC L-AMINO-ACIDS
Mag. Delvado et al., KINETICS OF THE FORMATION AND HYDROLYSIS OF THE SCHIFF-BASES OF PYRIDOXAL 5'-PHOSPHATE AND COPOLYPEPTIDES CONTAINING L-LYSINE AND AROMATIC L-AMINO-ACIDS, Journal of molecular catalysis. A, Chemical, 111(3), 1996, pp. 193-201
We determined the apparent rate constants of formation (k(1)) and hydr
olysis (k(2)) of the Schiff bases formed between pyridoxal 5'-phosphat
e and copolymers of L-lysine-L-tyrosine and L-lysine-L-phenylalanine,
at different pH values, at temperature of 25 degrees C and an ionic st
rength of 0.1 M. The values of the rate constant of formation obtained
for the systems of the present work are greater than these for the PL
P-poly-L-lysine system in all the range of pH studied, due to the pres
ence of aromatic groups in the lateral chains of the polypeptide. The
existence of these groups favors the presence of a few polar environme
nt for the Schiff bases.