SYNTHESIS AND EVALUATION OF NOVEL 1,5-BENZODIAZEPINES AS POTENT AND SELECTIVE CCK-B LIGANDS - EFFECT OF THE SUBSTITUTION OF THE N-5 PHENYL WITH ALKYL-GROUPS

Authors
FINIZIA G DONATI D OLIOSI B TRANQUILLINI ME URSINI A
Citation
G. Finizia et al., SYNTHESIS AND EVALUATION OF NOVEL 1,5-BENZODIAZEPINES AS POTENT AND SELECTIVE CCK-B LIGANDS - EFFECT OF THE SUBSTITUTION OF THE N-5 PHENYL WITH ALKYL-GROUPS, Bioorganic & medicinal chemistry letters, 6(24), 1996, pp. 2957-2962
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
24
Year of publication
1996
Pages
2957 - 2962
Database
ISI
SICI code
0960-894X(1996)6:24<2957:SAEON1>2.0.ZU;2-Z
Abstract
The synthesis and biological evaluation of both 3-ureido and 3-carbama te derivatives of 1,5-benzodiazepines bearing bulky alkyl substituents at N-1 and N-5 positions is reported. Their activity as CCK-B recepto r antagonists is discussed and compared with the related N-5-phenyl de rivatives. Copyright (C) 1996 Elsevier Science Ltd