A MODEL FOR THE TAXOL (PACLITAXEL) EPOTHILONE PHARMACOPHORE/

Authors
WINKLER JD AXELSEN PH
Citation
Jd. Winkler et Ph. Axelsen, A MODEL FOR THE TAXOL (PACLITAXEL) EPOTHILONE PHARMACOPHORE/, Bioorganic & medicinal chemistry letters, 6(24), 1996, pp. 2963-2966
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
24
Year of publication
1996
Pages
2963 - 2966
Database
ISI
SICI code
0960-894X(1996)6:24<2963:AMFTT(>2.0.ZU;2-2
Abstract
Epothilone is a recently discovered compound that appears to bind at t he same microtubule-binding site as the anticancer agent taxol. A mode l for the pharmacophore common to these structurally dissimilar compou nds is presented. Copyright (C) 1996 Elsevier Science Ltd