Twenty-two Nobel laureates in the fields of chemistry, physics, and me
dicine and physiology from Europe and the United States were interview
ed according to a systematic research protocol focused on in-progress
creative work. Twelve of these subjects had also participated in a con
trolled experiment involving word-association tasks. Documentary inves
tigations were separately carried out on autobiographical accounts and
work-in-progress manuscripts pertaining to the creative formulations
and discoveries of outstanding scientists of the past-Bohr, Darwin, Di
rac, Einstein, Planck, and Yukawa. Included was a personal account by
Einstein about the breakthrough idea leading to the general theory of
relativity. Overall analysis of the data regarding the creative work o
f the contemporary outstanding scientists and those of the past indica
ted the significant role in scientific creation of the janusian proces
s (''actively conceiving multiple opposites or antitheses simultaneous
ly''). This process was found to be complex, involving four phases dev
eloping over extended periods of time. The phases, described and docum
ented in this article, are motivation To create; deviation or separati
on; simultaneous opposition or antithesis; and construction of the the
ory, discovery, or experiment.