IDENTIFICATION AND BIOLOGICAL-ACTIVITY OF NOVEL PEPTIDOMIMETIC GASTRIN CCK-B RECEPTOR AGONISTS/

Authors
SEMPLE G RYDER H KENDRICK DA BATT AR MATHEWS E ROOKER DP SZELKE M NISHIDA A MIYATA K
Citation
G. Semple et al., IDENTIFICATION AND BIOLOGICAL-ACTIVITY OF NOVEL PEPTIDOMIMETIC GASTRIN CCK-B RECEPTOR AGONISTS/, Bioorganic & medicinal chemistry letters, 6(24), 1996, pp. 2971-2976
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
24
Year of publication
1996
Pages
2971 - 2976
Database
ISI
SICI code
0960-894X(1996)6:24<2971:IABONP>2.0.ZU;2-D
Abstract
The design, synthesis and biological activity of two novel series of c ompounds derived from the basic Boc-CCK-4 structure which provide pote nt ligands for the gastrin/CCK-B receptor is outlined. Within these se ries, new pseudopeptide compounds were discovered which unexpectedly w ere functional agonists in vivo, as shown by their ability to stimulat e basal gastric acid secretion in rats, an effect which was blocked by the potent gastrin/CCK-B receptor antagonist YM022. Copyright (C) 199 6 Elsevier Science Ltd