RECOGNITION OF A G-C BASE-PAIR BY ALPHA-N-7-DEOXYINOSINE WITHIN THE PYRIMIDINE-PURINE-PYRIMIDINE DNA TRIPLE-HELICAL MOTIF

Authors
MARFURT J HUNZIKER J LEUMANN C
Citation
J. Marfurt et al., RECOGNITION OF A G-C BASE-PAIR BY ALPHA-N-7-DEOXYINOSINE WITHIN THE PYRIMIDINE-PURINE-PYRIMIDINE DNA TRIPLE-HELICAL MOTIF, Bioorganic & medicinal chemistry letters, 6(24), 1996, pp. 3021-3024
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
24
Year of publication
1996
Pages
3021 - 3024
Database
ISI
SICI code
0960-894X(1996)6:24<3021:ROAGBB>2.0.ZU;2-P
Abstract
The alpha-nucleoside 7-(2'-deoxy-alpha-D-ribofuranosyl)hypoxanthine, i ncorporated into an otherwise beta-configured oligodeoxynucleotide tha t is designed to bind to a DNA duplex in the parallel motif, recognize s selectively and efficiently a G-C base pair, presumably via monodent ate alpha-H-7 . G-C base-triple formation. Copyright (C) 1996 Elsevier Science Ltd